Christopher B Eckman Selected Research

CP 113818

10/2004

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

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Christopher B Eckman Research Topics

Disease

21	Alzheimer Disease (Alzheimer's Disease) 12/2019 - 01/2003
4	Globoid Cell Leukodystrophy (Krabbe Disease) 04/2010 - 09/2005
3	Amyloid Plaque 01/2013 - 08/2004
3	Acute Liver Failure (Fulminant Hepatic Failure) 04/2011 - 06/2006
2	Brain Edema (Cerebral Edema) 08/2006 - 06/2006
2	Dementia (Dementias) 07/2006 - 08/2004
2	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2006 - 07/2006
2	Type 2 Diabetes Mellitus (MODY) 04/2004 - 04/2003
1	Neuroblastoma 01/2014
1	Hypertension (High Blood Pressure) 01/2013
1	Hemorrhage 05/2012
1	Necrosis 05/2012
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 04/2010
1	Coma (Comas) 05/2008
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 06/2007
1	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 06/2007
1	Traumatic Brain Injuries (Traumatic Brain Injury) 08/2006
1	Stroke (Strokes) 08/2006
1	Cerebrospinal Fluid Leak 08/2006
1	Parkinson Disease (Parkinson's Disease) 07/2006
1	Edema (Dropsy) 06/2006
1	Brain Injuries (Brain Injury) 06/2006
1	Malformations of Cortical Development 01/2006
1	Fabry Disease (Fabry's Disease) 09/2005
1	Nervous System Diseases (Neurological Disorders) 09/2005
1	Down Syndrome (Down's Syndrome) 08/2004
1	Cognitive Dysfunction 08/2004

Drug/Important Bio-Agent (IBA)

11	Amyloid beta-PeptidesIBA 07/2007 - 01/2003
7	Peptides (Polypeptides)IBA 01/2019 - 01/2003
6	Amyloid (Amyloid Fibrils)IBA 01/2019 - 10/2004
4	EnzymesIBA 12/2016 - 09/2005
4	GalactosylceramidaseIBA 04/2010 - 09/2005
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2014 - 06/2007
3	Proteins (Proteins, Gene)FDA Link 07/2007 - 01/2006
2	Endothelin-Converting EnzymesIBA 01/2013 - 01/2003
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2012 - 06/2006
2	Cholinergic Agents (Cholinergics)IBA 05/2010 - 08/2004
2	Insulin (Novolin)FDA Link 04/2004 - 04/2003
2	Insulysin (Insulin-Degrading Enzyme)IBA 05/2003 - 04/2003
1	IronIBA 12/2019
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2014
1	EstersIBA 01/2014
1	Metalloproteases (Metalloproteinases)IBA 01/2013
1	OccludinIBA 04/2011
1	ErbB Receptors (EGF Receptor)IBA 04/2011
1	Pharmaceutical PreparationsIBA 01/2011
1	Fluorescein (Funduscein)FDA LinkGeneric 05/2008
1	Prion ProteinsIBA 06/2007
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 07/2006
1	Dopamine D3 ReceptorsIBA 07/2006
1	7-hydroxy-2-N,N-dipropylaminotetralinIBA 07/2006
1	Oxidopamine (6 Hydroxydopamine)IBA 07/2006
1	N- (2(R)- 2- (hydroxamidocarbonylmethyl)- 4- methylpentanoyl)- L- tryptophan methylamideIBA 06/2006
1	Monoclonal AntibodiesIBA 06/2006
1	Matrix Metalloproteinases (MMPs)IBA 06/2006
1	CP 113818IBA 10/2004
1	Cholesterol Esters (Cholesteryl Esters)IBA 10/2004
1	Cholesterol 24-Hydroxylase (CYP46A1)IBA 08/2004
1	Mixed Function Oxygenases (Monooxygenases)IBA 08/2004
1	CholesterolIBA 08/2004
1	Estrogens (Estrogen)FDA Link 08/2004
1	tau Proteins (tau Protein)IBA 08/2004
1	Testosterone (Sustanon)FDA Link 06/2003

Therapy/Procedure

2	Therapeutics 05/2012 - 07/2006
1	Hepatectomy 05/2012
1	Decompressive Craniectomy 08/2006
1	Decompression 08/2006
1	Enzyme Replacement Therapy 09/2005